Makampani opanga mankhwala akukulitsa utoto wawo popanga mankhwala ambiri azamankhwala komanso masewera. Anthu ambiri amakhulupirira kuti zakhala zosavuta kupanga ndalama zothandizira matenda osiyanasiyana mu matekinoloje atsopano. Ndi anthu ochepa okha omwe amadziwa kuti zambiri mwazinthu zatsopano zomwe zidawonekera pamsika pambuyo pa 2000 ndizomwe asayansi azaka za m'ma 20 akutukuka. Ma ARV ndi otchuka kwambiri pamasewera tsopano. Ndalamazi zidapangidwa mzaka zam'ma 40 zam'zaka zapitazi kuti zithandizire matenda omwe amabwera chifukwa chosowa testosterone ndi mahomoni ena. Komanso, mankhwalawa adagwiritsidwa ntchito kupweteketsa minofu ndikukula ndikuchepetsa kwa ana.
Chidule Ma ARV adalandira dzina lotere kuti ogula azivuta ndipo amayimira Selective Androgen Receptor Modulators. Pogwira ntchito, amasiyana pang'ono ndi othandizira mahomoni, kupatula pakakhala zovuta. Ubwino waukulu wama modulators ndimomwe amathandizira pakukula ndikukula kwa minofu.
Kodi ma SAR amasiyana bwanji ndi anabolic steroids?
Wothamanga aliyense wagwiritsa ntchito zida zingapo zakuthupi pantchito yawo yonse. Mankhwala onse ndi zowonjezera masewera zimasiyana mosiyanasiyana, katundu, ndipo, kupezeka kwa zovuta. Kuyambira kutulutsidwa kwa Ma ARV, akhala othandiza kwambiri. Tsopano wothamanga aliyense wachinayi amakonda ma androgen receptor modulators, mosiyana ndi zomwe ambiri amakhulupirira. Asanapange ndalamazi, mahomoni a anabolic anali kugwiritsidwa ntchito mwakhama. Ndizovuta kwambiri kwa oyamba kumene kusankha pakati pa ma steroids ndi Ma ARV chifukwa cha kutaya mafuta kapena kupindula kwa minofu. Izi ndichifukwa chazidziwitso zochepa zazinthu zoterezi.
Zomwe zimasiyanitsa ma SAR ndi izi:
- Kupanda kununkhira bwino pamaphunziro ndi zotsatira zake monga kuchuluka kwamadzi.
- Silimapondereza testosterone wachilengedwe.
- Thandizo lothandizira pakatha maphunzirowa silofunikira.
- N'zotheka kupeza minofu popanda jakisoni.
- Osasandulika dihydrotestosterone.
- Itha kuphatikizidwa ndi mankhwala ena, mosasamala kanthu za kapangidwe kake.
- Mtengo wotsika mtengo, malamulo, osayesa kugwiritsa ntchito mankhwala osokoneza bongo.
- Kulimbikitsa chitetezo cha mthupi.
Ndikofunikira kukumbukira kuti mutha kugwiritsa ntchito ma SAR mosatengera kuti ndinu amuna kapena akazi. Mapiritsiwa akhala othandiza kwambiri pamasewera ndi zamankhwala. Oyamba kumene ambiri amafunsa funso lomwelo - ndi njira iti yomwe ingagwiritsidwe ntchito bwino pamasewera? Funso ili lidzakhala losayankhidwa; popeza mankhwala aliwonse ali ndi mikhalidwe yabwino komanso yoyipa, kusankha kumakhala kwa wothamanga nthawi zonse.
Mitundu ya ma SAR
aliyense masewera sitolo ili ndi mankhwala osiyanasiyana komanso zowonjezera, Ma ARV. Wogulitsa amapatsa wogula chinthu chopindulitsa kwambiri kwa iwo, koma wothamanga ayenera kumvetsetsa mitundu ya ma SAR kuti asankhe choyenera kwambiri kwa iwo.
Pali mitundu iwiri yayikulu ya ma modulators:
- Steroids adapangidwa koyambirira kwa zaka zapitazi ndipo adagwiritsidwa ntchito kwanthawi yayitali ngati zamankhwala mpaka zaka za m'ma 90 za m'ma 20. Amakhala ofanana ndi ma steroids koma amakhala ndi zovuta zochepa.
- Gulu losakhala steroidal limakhala ndi mavairasi pamasewera akatswiri. Zimathandizira kuchita masewera olimbitsa thupi popanda kusokonezedwa ndi mahomoni ndipo zimakhala ndi zovuta monga mawonekedwe a estrogenic. Ngati wothamanga asankha kugwiritsa ntchito mankhwala amtunduwu pamasewera, ayenera kudzidziwitsa okha ma nuances onse ndikumvetsetsa omwe amapanga ma SAR ndi omwe amadziwika kwambiri ndipo amafunidwa pamasewera .
MK2866. Izi ndiye zabwino koposa mtundu wa SARM zomwe zaphunziridwa. Amadziwikanso kuti Ostarine. Kafukufuku wasonyeza kuti MK-2866 imathandiza kwambiri kumanga minofu, ndipo ndi yopindulitsa chifukwa ilibe zovuta zambiri. Ndi MK-2866, mutha kuyembekezera kuti mukulitsa minofu yanu mwezi uliwonse.
YK11. Inapezeka ndi Yuichito Kanno ndipo ndi imodzi mwazinthu za ma SAR abwino chifukwa ndizopindulitsa kwambiri pakutha kwa mafuta komanso kumanga minofu popanda kuvutika ndi zovuta zina monga kuwonongeka kwa chiwindi kapena kuthamanga kwa magazi.
RAD140. Amadziwikanso kuti Testolone ndipo ndi amodzi mwamphamvu kwambiri ma SAR omwe amapezeka pamsika. Mumawonjezera minofu ndi mphamvu. Zimalimbikitsanso libido.
LGD4033. Nayi ina mtundu wa SARM ndizomveka bwino. Ligand Pharmaceuticals adayamba kupanga izi, adakumana ndi mayesero ambiri amunthu, ndipo atsimikizira kuti ndi mankhwala osangalatsa.
Kafukufuku wathanzi Amuna omwe adatenga LGD4033 masiku makumi awiri ndi chimodzi awonetsa kuti mankhwalawa amachulukitsa thupi. Chokhacho chotsatira chake ndikuchepetsa kwakanthawi kwa testosterone. Kutenga milligram imodzi ya LGD4033 patsiku kumatulutsa kukula kwakukulu kwa minofu, koma mulingo wake umakhala wabwino, zotsatira zake zimakhala zabwino.
SR9009. Ichi ndi china chotchuka mtundu wa SARM. Mu mbewa, izi zawonetsedwa kuti zimathandizira kukula kwa minofu ya mitochondrial, kuchepetsa kutupa, kuwonjezera kupirira, ndikuthandizira kukhetsa mafuta amthupi. Komabe, makoswe anapatsidwa SR9009 ngati jakisoni. Mukamutenga pakamwa, sichingakhale ndi zotsatira zofananira ndi 2% bioavailability ndipo idzachotsedwa m'dongosolo mukangotenga.
MK677 Izi ndizochulukirapo, ndipo m'malo mopondereza mahomoni okula mthupi lanu, zimawonjezera. Ndi MK677, mutha kuyembekezera kuwonjezeka kwachangu kwa njala, kuchuluka kwa zokolola, komanso kuchepa kwamafuta.
S-23. Ndi non-steroidal mtundu wa SARM yomwe imagwira pakamwa ndikugwira bwino ntchito yolandila a androgen, zomwe zimapangitsa kuchuluka kwa minofu ndikuchepetsa mafuta.
Momwe mungagwiritsire ntchito ma SARM molondola?
zingapo mitundu ya SARMs itha kugwiritsidwa ntchito pochita masewera. Kutengera mtundu wa mankhwala ndi momwe amagwirira ntchito, mutha kuwerengera mlingowo molondola ndikukwaniritsa bwino miyezi ingapo yogwiritsira ntchito.
Ndikofunikira kusankha mankhwalawa makamaka pazolinga ndi zokumana nazo:
- Ostarine (MK-2866) ndiyabwino kwa oyamba kumene; imagwira ntchito mwachangu komanso modekha popanda kusokoneza dongosolo la mahomoni ndi thanzi. Izi mtundu wa SARM siowopsa, koma imatha kuthamangitsa minofu ndikunyamula moyenera moyenera.
- Kwa akatswiri, Ligandrol (LDD-4033) ipereka kukula kwa minofu, kuwonjezera mphamvu, komanso kupewa katemera. Ndi mankhwala amphamvu; chifukwa chake, nthawi zambiri amagwiritsidwa ntchito ndi akatswiri ochita masewera. Mlingowo ndi wosavuta, kapisozi mmodzi patsiku la mankhwala aliwonse mukatha kudya.
- Kuchepetsa thupi mosasamala jenda ndi kunenepa kwambiri, Cardarine (GW501516) ndioyenera kuwotcha mafuta mwachangu. Ambiri sadziwa momwe angatenge SARs ndikuwerengera kuchuluka kwake. Choyipa chachikulu, anthu samvetsetsa kuti sikoyenera kudikirira zotsatira mukangomwa mapiritsi. Kuti muchepetse kunenepa kwambiri, muyenera kupanga zakudya zapadera ndi masewera olimbitsa thupi. Ochita masewerawa amagwiritsa ntchito mankhwalawa poyanika kuti athetse vuto la minofu.
Chonde dziwani kuti zovuta zimatha ngati mutagwiritsa ntchito Ma ARV. Koma ngati wothamangayo atanyalanyaza mlingo ndikuugwiritsa ntchito kwa nthawi yopitilira milungu 12, zisokonezo zazing'ono pantchito yathunthu zitha kuchitika.
Kodi mumagwiritsa ntchito ma SAR?
osiyana mitundu ya ma SAR itha kugwiritsidwa ntchito kukwaniritsa zolinga zilizonse zolemetsa, kuonda, kupirira komanso kuthamanga / kupeza mphamvu, ndi zina zambiri.
Kuphatikiza kolondola kwa angapo Ma ARV ikuthandizani kuti mukwaniritse bwino Zotsatira.
Kawirikawiri, ma SAR amagwiritsa ntchito kayendedwe Zimatenga masabata 12 mpaka 16, kutengera ndi iti mtundu wa SARM mumasankha.
Pali zochitika zingapo zomwe zingagwiritsidwe ntchito ma SAR:
- The Ma ARV Inde ndi yotchuka kwambiri ngati mlatho wotchedwa pakati pa kugwiritsa ntchito anabolic steroids osataya zotsatira zonse zamaphunziro.
- Kugwiritsa ntchito maphunziro a SARM panthawi yamankhwala ophunzirira pambuyo pake.
- Kugwiritsa ntchito ma SAR pamayendedwe a anabolic steroid kupititsa patsogolo zotsatira za ma steroids.
- Kungogwiritsa ntchito ma SAR kuti mukwaniritse zolinga zanu mukamagwira ntchito.
Ma ARV kukhala kwambiri ubwino kuti munthu wamba adye, ndipo maubwino awa ndiofunikira. Ma ARV ndiye njira yokhayo yotetezeka yomwe mungakulitsire masewera anu.
Ubwino wa ma SAR
Ma SAR amachita ngati ma steroid osayambitsa zovuta zina zomwe ma steroid angayambitse.
Kuphatikiza apo, ma SAR ali ndi zabwino zambiri:
- Njira yoyendetsera pakamwa.
- Zotsatira zabwino zimaphatikizapo kutenga testosterone (kuchuluka kwa libido, kulimbitsa mafupa ndi mitsempha, kuwotcha mafuta, kukula kwa minofu yowonda, ndi zina zambiri)
- Palibe kutembenukira ku DHT (dihydrotestosterone, palibe vuto pakukula kwa tsitsi lakumutu ndikutaya tsitsi la khungu).
- Osatembenuzidwa kukhala estrogen.
- Osati poizoni pachiwindi, mosiyana ndi mankhwala a methylated monga prohormones ndi oral steroids.
- Palibe mphamvu pa testosterone.
- Ndizovomerezeka kwathunthu.
Ma SAR akhoza kukuthandizani kwambiri kukwaniritsa zolinga zanu zomanga thupi. Komabe, ndikofunikira kuti tipewe kuwagwiritsa ntchito mopitirira muyeso komanso kugwiritsa ntchito luntha posankha fayilo ya ma SAR abwino zanu.
Monga chinthu chilichonse chopangira, kuthekera kwa zotsatirapo kulipo. Kuwopsa kwake kumakhala kotsika kwambiri kuposa njira zina monga testosterone, komabe kulipobe.
Kumbukirani kuti palibe bungwe lovomerezeka lomwe limayang'anira mtundu wa ma SAR. Ngati mungasankhe kuwalandira kuti akwaniritse zolinga zanu, yang'anani opanga odziwika komanso owunikiridwa bwino