SARMS KWA TESTOSTERONE Yotsika
Ma ARV Ochiza Hypogonadism
M'zaka zaposachedwa, kuchuluka kwa anthu kumakhudzidwa ndimatenda osiyanasiyana komanso zovuta. Matenda omwe amafalikira pang'onopang'ono koma mosalekeza ndi Male hypogonadism, amatchedwanso kuchepa kwa testosterone. Munkhaniyi, tikhala tikuwerenga zaumoyowu komanso momwe ma modulators a androgen receptor angagwiritsidwe ntchito pochizira hypogonadism.
Hypogonadism-Mwachidule
Hypogonadism yamwamuna imatha kuwerengedwa ngati thanzi momwe thupi la munthu silipanga testosterone yambiri. Kumbukirani, testosterone ndiye mahomoni omwe amatenga gawo lofunikira kwambiri pakukula kwamwamuna ndikukula pakamatha msinkhu. Matendawa atha kugwiritsidwanso ntchito kutanthauza kusokonekera kwa thupi kutulutsa umuna.
Hypogonadism itha kukhala momwe munthu amabadwira kapena itha kukulira pambuyo pake, nthawi zambiri kuchokera ku matenda kapena kuvulala. Hypogonadism yamwamuna imatha kuthandizidwa ndimankhwala osankhidwa a androgen receptor modulators.
Zosankha za Hypogonadism Treatment
M'mbuyomu, kukonzekera ma testosterone angapo kunkagwiritsidwa ntchito pochiza hypogonadism mwa mwamuna wokalamba. Mankhwalawa amasiyana mosiyanasiyana m'zigawo, kusinthasintha, ndalama, komanso mosavuta. Mwa mankhwala onse omwe alipo, chithandizo cha Selective androgen receptor modulators (SARMs) chimawerengedwa kuti ndi chabwino kwambiri. Izi ndichifukwa choti ma SAR amawonetsa ndikupereka zabwino za anabolic pakalibe zotsatira za androgenic pa tsitsi, khungu, ndi prostate.
Ndikofunikira kudziwa apa kuti hypogonadism yoyambira mochedwa imaphatikizira mndandanda wazizindikiro kuphatikiza kutopa, kulephera kugonana, kuchepa kwa thupi, komanso kuchepa kwa mchere wamafupa. Zizindikiro zonsezi zimakhudzana ndi kuchepa kwa testosterone ndipo nthawi zambiri kumayendetsa wodwalayo kukafunafuna chithandizo chamankhwala.
Mu 1990s, Selective androgen receptor modulators (SARMs) adanenedwa ngati nonsteroidal androgen receptor agonists. Makinawa anali ndi pharmacology yapadera ndipo amagwiritsa ntchito ma agonist athunthu m'matenda a anabolic monga mafupa ndi minofu koma agonists osagwirizana amtundu wa androgenic monga khungu, tsitsi, ndi prostate. Ubwino wapaderawu komanso wosayerekezeka wa Selective androgen receptor modulators adadziwika nthawi yomweyo ndi ofufuza ndi akatswiri azachipatala.
Mwachitsanzo, Ostarine (Zovuta) idawunikidwa kuti ndi yothandiza komanso yothandiza pakagwiridwe ka thupi ndi kapangidwe ka thupi m'maphunziro osiyanasiyana azachipatala. Pakafukufuku, 3mg ya Ostarine kapena placebo idaperekedwa kwa azimayi 48 omwe atha msambo kwa milungu 12. Ostarine idakulitsa kwambiri thupi lowonda poyerekeza ndi placebo (1.54 kg; P <0.001). Osati izi zokha, Ostarine (yemwenso amadziwika kuti MK-2866) idakulitsa kuchuluka kwa minofu ya ntchafu ndi 0.17L kuchokera koyambira mpaka tsiku 84 poyerekeza ndi kuchepa kwa 0.12L pagulu la placebo. Kuwonjezeka kwa ma 22 lbs kunawonedwa mu mphamvu yamiyendo yamiyendo mgulu la Ostarine poyerekeza ndi 1.5 lb yokha mwa odwala omwe alandila placebo.
Pakafukufuku wosiyanasiyana wa mayankho, anthu adalandira placebo kapena Ostarine pamlingo wa 0.1, 0.3, 1.0, kapena 3.0 mg kwamasabata 12. Kafukufukuyu anali okhudza amuna 120 okalamba athanzi osakwanitsa zaka 60 komanso amayi omwe atha msambo. Mlingo wa Ostarine modalira umakulitsa kuchuluka kwa thupi lowonda ndikuchepetsa mafuta ochuluka nthawi yomweyo. Ostarine pamlingo wa 3.0 mg idachulukitsa thupi lowonda ndi 1.3kg (P <0.001) yomwe idatsagana ndikuchepetsa pafupifupi 0.6kg (P = 0.049) mu mafuta athunthu okhudzana ndi placebo. Kafukufukuyu adawonetsanso kuchuluka kwakukwera kwamphamvu pamakwerero (P = 0.013). Awonetsanso kusintha kwakanthawi kofunikira kukwera masitepe 12.
Pakafukufuku wina, Ostarine ndi placebo zidaperekedwa kwa odwala 159 omwe ali ndi khansa zosiyanasiyana. Kafukufukuyu adawonjezeka modabwitsa patatha miyezi inayi ya chithandizo cha Ostarine potengera thupi lathunthu loonda pa 1.0 mg (1.5kg; P = 0.0012) ndi 3.0 mg (P = 0.046). Kuphatikiza apo, panali kuwonjezeka kwapakati pa 18% kwa 1mg (P = 0.001) ndi 21.7 peresenti ya 3mg (P = 0.0065 ku 3mg) yowonedwa pakukwera kwamphamvu ndi kusintha kwakanthawi munthawi yofunikira kukwera masitepe 12.
Zambiri zama testosterone zomwe zimavomerezedwa pochiza hypogonadism zimafunikira makonzedwe a makolo. Mulingo wa testosterone ukhoza kubwezeretsedwanso mokhazikika momwe mungagwiritsire ntchito njira zosiyanasiyana zoperekera. Komabe, zambiri mwazinthu izi zikagwiritsidwa ntchito kudzera mu jakisoni wa mnofu zimabweretsa kusinthasintha kwakukulu pakufalitsa testosterone. Kuphatikiza apo, amatenga nthawi yayitali (masabata a 2-14) omwe amaletsa kusintha kwamankhwala mwachangu kapena kutha pakagwa zovuta.
Kumbali inayi, ma SAR monga Ostarine amatha kukhala ndi mwayi wa anabolic pamiyeso yotsika ya milligram. Mankhwalawa omwe samapezeka pakamwa amadziwikanso ndi kuchotsa kwa theka la miyoyo yomwe imabweretsa kusinthasintha kocheperako. Khalidwe ili limapangitsanso ma SAR kukhala othandiza kamodzi patsiku.
Gulani zenizeni, zowerengera, komanso zabwino Ostarine tsopano kuchokera kuzabwino Ma ARV UKsitolo - the Masitolo a SARM pamtengo wokwanira modabwitsa.