Ma SARs a Thermal Replacement Therapy
M'zaka zaposachedwa, kuchuluka kwamphamvu kwa anthu kwawonetsa kuti asayansi ndi ofufuza akudzipereka kwambiri kulimbana ndi ukalamba wa anthu.
Amuna ndi akazi akamakula, mphamvu ya minyewa yawo, minofu yawo, ndi mphamvu ya mwendo wawo zimachepa chifukwa chakuchepa kwa mafupa a mafupa, makamaka ulusi wachiwiri. Izi zimabweretsa chiopsezo chowonjezeka cha fractures, kugwa, ndi kulemala. M'mbuyomu, asayansi ankakonda kunena zamankhwala a anabolic koma tsopano asinthidwa moyenera ndi ma androgen modulators (SARMs) omwe amatha kupeza zotsatira za anabolic popanda zovuta.
Chimodzi mwamaubwino akulu kwambiri a modulators osankha a androgen receptor Kodi ndizokonzekera mwamphamvu pakamwa ndi mbiri yotetezeka komanso yothandiza. Zipangizo zamphamvu izi zimatha kusankha minyewa yamtundu wa minofu kuti ikalimbikitse kubwezeretsa moyenera kwa magwiridwe antchito omwe nthawi zambiri amalamulidwa ndi ma androgen amkati.
Kupita kwaposachedwa kukuwonetseratu kuti lingaliro lakuthandizira kusintha kwa mahomoni likusintha kwambiri, pakugwiritsa ntchito kuchuluka kwake ndi mitundu ingapo yamapulogalamu omwe atha kukhala opindula ndi izi.
Kupanga ndi kutsatsa kwa ma modulators a androgen receptor modulators amathandizidwa ndi zidziwitso zam'mbuyomu zamankhwala komanso zamankhwala zamaganizidwe omwe amatha kupangidwa ndimankhwala osankhidwa mwapadera. Izi zimachitika ndicholinga chofunikiranso kulandira ma androgen receptors kuti athetse zovuta zina ndikukhalitsa ndikuwonjezera chitetezo ndi zotsatira zoyipa zakusankhira kulandila kwa receptor.
Udindo wa ma ARV mu Androgen Therapy for Men
Pakadali pano, mitundu ya androgenic yothandizila m'malo mwake imangokhala yoperekera khungu kapena jakisoni wa testosterone kapena testosterone esters. Komabe, mitundu ya jakisoni ya testosterone esters (monga testosterone cypionate kapena enanthate) imapanga kusinthasintha kosafunikira komanso kosokoneza kwamwazi wama testosterone.
Izi zimalumikizidwa ndimatenda am'magawo oyamba ndi magawo abwinobwino kumapeto kwa nthawi isanakwane jekeseni lotsatira lomwe limapereka mawonekedwe osakwanira kwathunthu komanso zoyipa nthawi zambiri. Kumbali inayi, kukonzekera pakamwa monga 17α-methyltestosterone ndi fluoxymesterone kumalumikizidwa ndi chiwindi cha chiwindi. Momwemonso, zigamba za khungu zimayambitsa kukwiya pakhungu ndikugwiritsa ntchito tsiku ndi tsiku kwambiri kumachepetsa kuvomerezeka ndi njira yothandizirayi.
Ma modulators a androgen receptor modulators amayang'ana zolandilira a androgen mosiyanasiyana m'matumba osiyanasiyana kuti apange zomwe akufuna. Ma ARV amagwira ntchito pakamwa ndipo amadziwika ndi mbiri ya pharmacokinetic yomwe imagwirizana kamodzi patsiku loyang'anira. Kuphatikiza apo, ali ndi kuthekera kolimbikitsa zotupa za semina, prostate, ndi ziwalo zina zoberekera pamiyeso yomwe imapatsa mphamvu iwo omwe akufunika kuti awonjezere mphamvu yamphamvu ndi minofu. Ma SAR amathandizanso kulimbikitsa kuchuluka kwamafuta, kubwezeretsa / kusunga libido, ndikuthandizira kukula kwa mafupa.
Kuthekera phindu la mankhwala a androgen Kugwiritsa ntchito ma androgen receptor modulators kumawonekera bwino kupitirira hypogonadism yoyambira kapena yachiwiri komanso kumadera omwe amaphatikizapo kuwononga kachilombo ka HIV ndi khansa ya cachexia, kufooka kwa mafupa kwa glucocorticoid, osteopenia ndi kufooka kwa mafupa kwa okalamba, kuchepa kwa magazi, kulera kwamwamuna, mitundu yosiyanasiyana ya ma dystrophies amisempha, ndi mitundu ina yambiri za zovuta.
Kafukufuku wazachipatala awonetsa kuti ma SAR ngati kuchuluka kwa 3mg tsiku lililonse a MK-2866 (Ostarine) operekedwa kwa amuna okalamba adadzetsa kuchuluka kwa minofu ndi 1.4kg (3.5lbs) mkati mwa miyezi itatu. Kuphatikiza apo, kugwiritsa ntchito Ostarine kumalumikizidwa ndi kuwonjezeka kwa kukwera masitepe kotuluka ndi 25 peresenti ndikufulumira ndi 15 peresenti. Kuphatikiza apo, kugwiritsa ntchito MK-2866 kumalumikizidwa ndi kuwonjezeka kwakukulu kwa moyo wabwino komanso moyo wabwino. Gulani Ostarine tsopano ndi yomwe imakonda kwambiri padziko lonse lapansi Masitolo a SARM.