Mbiri ndi Zomwe Zili M'ma SAR-Evolution Of SARMs
Mankhwala osokoneza bongo akhala akusangalatsa komanso kukopa chidwi cha anthu. Kuchokera kwa Aroma Akale mpaka kwa Agiriki, kugwiritsa ntchito zinthu zolimbitsa thupi monga machende a nyama ndi zitsamba kunali kofala komanso kodziwika padziko lonse lapansi. Popita nthawi, zinthuzi zidasinthidwa ndi mankhwala a anabolic ndi ma prohormones omwe amathandiza othamanga ndi omanga thupi kuswa mapiri ndikupeza malire osiyana ndi othamanga achilengedwe. Komabe, panali zoopsa zazikulu ndikugwiritsa ntchito mankhwalawa ndipo zoopsa zake ndizokulirapo kuposa phindu.
Ichi chinali chimodzi mwazifukwa zomwe mankhwala a anabolic adaletsedwera ndi magulu amasewera ndi maboma apadziko lonse lapansi chifukwa cha zovuta zoyipa zomwe zimakhudzana nawo. Izi ndi nthawi zomwe dziko lokonzekera masewera olimbitsa thupi komanso masewera othamanga limayang'ana njira ina yotetezeka ndikubwera Ma modulators osankhidwa a androgen (Ma ARV).
Ma modulators a androgen receptor modulators adatchuka pambuyo poti zovuta za mankhwala monga steroids zidawunikidwa ndimaphunziro osiyanasiyana azachipatala ndi kafukufuku. Anabolic steroids omwe kale anali kupatsidwa kale nthawi zonse amayenera kusinthidwa ndi njira zina zotetezeka komanso zamphamvu. Ogulitsa anali kufunafuna otetezera komanso otsogola omanga minofu omwe angagulidwe mosavuta komanso mochenjera pa intaneti m'malo mochita ndi anthu amdima omwe amakhala muzipinda zosanjikiza.
Kupezeka ndi kutchuka kwa ma SAR mu gulu la asayansi mosakayikira chinali chochitika chofunikira kwambiri kwa mabungwe onse olimbana ndi ukalamba komanso azachipatala. Chomwe chimadetsa nkhawa kwambiri ndi mankhwala a androgen chinali kupezeka kosowa kwa mankhwala otetezeka komanso amphamvu oti azigwira popanda zovuta zomwe zimayambitsidwa ndi kuwongolera kwakanthawi kwa ma androgens achilengedwe.
Cholinga chachikulu cha ofufuza ambiri a SARM chinali kudziwa zambiri za agonists a receptor ya androgen popanda kuthekera kolumikizana ndikugwira ntchito ngati magawo a aromatase ndi 5a-reductase. Popita nthawi, makampani opanga mankhwala ndi ofufuza adakwanitsa kupanga makamaka zitadziwika kuti zosintha zamankhwala za bicalutamide, anti-androgen, zopangira ma androgen ndi zochitika za agonistic. Posakhalitsa, magulu osiyanasiyana a Selective androgen receptor modulators adadziwika ndikupangidwa.
Makampani akuluakulu opanga mankhwala anali kumbuyo kwa izi kuti athetse mavuto azaumoyo osati pantchito zomanga thupi. Mwachitsanzo, amafuna kupanga mankhwala othandiza kupewa kuwonongeka kwa minofu mwa odwala omwe ali ndi khansa ndi HIV / AIDS.
Kodi ma ARV Amagwira Ntchito Bwanji?
Minofu ya minofu imayamba kuchepa ndikamakalamba chifukwa chakuwonongeka komanso kutayika kwa mtundu wa 2 ulusi waminyewa. Mtundu wa minofu yamtunduwu ndiwofunikira kwambiri pamphamvu, kupirira, komanso kukhala wathanzi ndipo kuchepa kwake kumatha kuyika pachiwopsezo pakugwira bwino ntchito tsiku ndi tsiku.
Kafukufuku wowerengeka wasonyeza kuti maphunziro ndi magwiridwe antchito ngati kukana kukana kungathandize pakukulitsa ndikusunga mtundu wa 2 wa fiber. Mulingo wamphamvu ndi minofu yowonda imatha kulimbikitsidwa mwa anthu omwe ali ndi vuto la androgen powonjezera Selective androgen receptor modulators mu kusakaniza.
Ma modulators a androgen receptor modulators amagwira ntchito mthupi kudzera:
- Kukaniza kwa aromatase komwe kumathandizira kusintha kwa testosterone kukhala estrogen.
- Kuwonetsa kuyanjana kwapadera ndi minofu ndi mafupa koma osati chiwindi, impso, prostate, ndimatenda amtima.
- Osasweka kukhala mamolekyulu owononga omwe akanatha kubweretsa zotsatira zoyipa za steroid.
- Osapondereza kupanga kwa mahomoni ngati testosterone.
Kuphatikiza pa maubwino awa, osankha a androgen receptor modulators samakhudza kapena kuyika zovuta m'thupi. Samatseka mwamphamvu kapena kosatha Hypothalamus-Pituitary-Testes-Axis (HPTA). Chofunika kwambiri ndikuti kugwiritsa ntchito ma SARM mosiyana ndi ma anabolic androgenic steroids sikubweretsa zovuta zina monga kukula kwa minofu ya m'mawere mwa amuna, khungu lamafuta, ziphuphu, kuwonongeka kwa prostate, kuchepa kwa machende mwa amuna, kukulira kwa mawu ndi kusamba kwachilendo kwa akazi, komanso kukula kwa tsitsi kumaso, m'mimba, komanso kumtunda.
Kuphatikiza apo, kugwiritsa ntchito mankhwala ndi ma SARM enieni pazithandizo zamankhwala ndi zamalamulo mogwirizana ndi malangizo azachipatala sizimayambitsa zovuta zina monga kukwiya, kuwonongeka kwa tsitsi, kuwonongeka kwa uchembere, kapena mavuto a prostate.
Kusiyanasiyana Mukusankha kwa Androgen Receptor Modulators
Imodzi mwa kusiyana kwakukulu pakati pa Ma modulators osankhidwa a androgenndipo mankhwala monga anabolic steroids ndiye kusinthika kwamapangidwe pakati pawo. Tiyenera kudziwa kuti gawo lirilonse lomwe limatha kumangirira wolandila wa androgen wa thupi ndikulowetsedwa munthawi inayake limatha kutchedwa Selective androgen receptor modulator.
Kwenikweni, izi zikutanthauza kuti palibe chifukwa chomveka chomangotchulira dzina poyerekeza ndi cha anabolic androgenic steroids (4-ring base).
Kusankha Ndi Chinsinsi
Njira yosankhira androgen receptor modulator yomwe imawonedwa ngati yothandiza kuchipatala iyenera kuwonetsa kukondera kwa minofu. Mwanjira ina, imayenera kuwonetsa agonist mu mafupa ndi minofu kwinaku ikuwonetsa kulumikizana pang'ono kapena kusagwirizana ndi ziwalo zachiwerewere zachiwerewere monga prostate ndi ma seminal vesicles.
Titha kunena kuti Selective androgen receptor modulator ndiyomwe imathandizira kukula kwa minofu koma imasiya prostate, chiwindi, tsitsi, ndi mabere okha. Kuphatikiza apo, SARM iyenera kukhala ndi zochitika za anabolic zofanana kapena zingapo pamizere ya Testosterone.
Momwe Alili Ma SAR Pa Mndandanda Woletsedwa WADA
Kuyambira 2008, Selective androgen receptor modulators aletsedwa ndi World Anti-Doping Agency (WADA). Izi ndichifukwa chosavuta kuti ma SAR ndi mankhwala osokoneza bongo omwe ali ndi zabwino zosiyanasiyana zomwe zitha kupatsa mpikisano wothamanga "mpikisano". Pakadali pano, ma modulators a Selective androgen receptor modulators amaletsedwa nthawi zonse mgulu la "othandizira ena a anabolic" motsogozedwa ndi Gawo S1.2 la Mndandanda Woletsedwa WADA. Izi zikutanthauza kuti muyenera kupewa kugwiritsa ntchito ma SAR kapena kuwagwiritsa ntchito mosamala ngati ndinu othamanga oyesedwa ngati kupezeka kwa Selective androgen receptor modulatorsm'masampuli anu mutha kukugwerani m'mavuto akulu.
Masiku Ano Kutchuka Kwa Ma SAR
Masiku ano, Selective Androgen Receptor Modulators amawonedwa ngati gulu lapadera la mamolekyulu omwe amatha kuthana ndi zovuta zochepa monga kufooka kwa mafupa, kuwonongeka kwa minofu, komanso kuchepa kwa androgen.
Ochita masewera olimbitsa thupi akugwiritsa ntchito ma SAR kuti ataye mafuta, achulukitse mafupa, ndikupeza minofu yowonjezerapo pomwe amakhala kutali ndi zovuta zoyipa zamankhwala monga anabolic androgenic steroids. Osati izi zokha, Selective Androgen Receptor Modulators ndizothandiza kwambiri pochotsa kutaya kwa libido, kusabereka, komanso kukhumudwa, kutopa, kudzidalira, komanso kunyinyirika pomwe mukukhalanso ndi thanzi labwino komanso kukhala bwino.
Kuphatikiza pa maubwino awa, ma SAR amakondedwa padziko lonse lapansi chifukwa cha kupezeka kwawo kwakukulu. Ubwino wapaderawu umawapangitsa kukhala oyenerera kugwiritsa ntchito moyenera ndi kuyamwa.
Pakadali pano, omanga thupi ambiri akugwiritsa ntchito mawonekedwe osungidwa azifukwa zomveka komanso zomveka. Fomu iyi ya Selective Androgen Receptor Modulators ili ndi maubwino ambiri:
- Ma SAR osankhidwandizosavuta kutumiza.
- Ali ndi nthawi yayitali kuposa ma SAR amadzi.
- Ma SARM omwe atsekedwa amakopeka kwambiri kwa ogwiritsa ntchito kumapeto (monga kugawana masingano kumapewa, mwayi wamatenda opatsirana pogonana amathetsedwa, komanso kuthekera kwa kupweteka kapena kutupa m'malo opangira jekeseni kumathetsedwa).
- Zosakaniza zina za SARM zimatha mphamvu ndikuchita bwino ngati madzi.
- Zosakanikirana ndi ma SAR amadzimadzi zimapangidwira kuti ziphatikizidwe ndi chakudya chopukutidwa ndikutuluka mthupi mwachangu. Kumbali inayi, ma SARM otsekedwa amapangidwa ndi cholinga chololeza thupi kuti litenge ndikusunga zochitika zabwino za ma SARM opindulitsa.
- Ma SAR osankhidwamulibe zowonjezera zosafunikira monga zonunkhira ndi zowonjezera.
Nzosadabwitsa kuti dziko lokonza zolimbitsa thupi likuchita misala chifukwa chazida zowonjezerazi zolimbitsa thupi zomwe zasinthiratu dziko lochita zolimbitsa thupi komanso kulimbitsa thupi kwambiri. Komabe, ndikofunikira kuti nthawi zonse muwonetsetse kuti ma modulators a Selective androgen receptor ayenera kugula nthawi zonse kuchokera kwa ovomerezeka Masitolo a SARMyomwe imagwira ntchito mochita kusankha moyenerera komanso mochita kafukufuku. Sitolo ya SARM yapaintaneti iyenera kupereka njira zodalirika zotetezera komanso mwayi wosankha mosamala ndikutumiza zinthuzo mutakuphunzitsani kwathunthu za mankhwalawa kuti mupange chisankho chanzeru nthawi zonse.
Kuphatikiza apo, kugwiritsa ntchito mankhwala amphamvu kwambiriwa kumayenera kuchitika nthawi zonse mogwirizana ndi malangizo azachipatala komanso pazithandizo zamankhwala komanso zovomerezeka. Mlingo wa ma SAR sayenera kuwonjezeredwa ndipo mankhwalawa sayenera kuzunzidwa poyembekeza kuti achite mwachangu chifukwa kugwiritsa ntchito mankhwala osokoneza bongo kumatha kubweretsa zovuta ndipo kusankha androgen receptor modulators sizosiyana nazo. Ma modulators a androgen receptor ndi mankhwala amphamvu omwe amayenera kugwiritsidwa ntchito moyenera nthawi zonse.