Ostarine MK-2866 ndi Osteoporosis: Kumvetsetsa SARMs for Bone Density 

Ostarine (yomwe imadziwikanso kuti MK-2866 ndi Ostabolic) ndi Selective Androgen Receptor Modulator yomwe nthawi zambiri imaperekedwa kwa odwala omwe ali ndi thanzi labwino monga osteoporosis. 

Tiyeni tiwone momwe Ostarine angaperekere mpumulo waukulu kwa anthu omwe ali ndi matenda osteoporosis. Izi zisanachitike, ndizomveka kuphunzira za matendawa ndi zomwe zimayambitsa, kuti mukhale ndi chidziwitso chomveka bwino komanso chokwanira. 

 

Kodi matendawa ndi otani?

Osteoporosis ndi vuto la thanzi lomwe limadziwika ndi kuwonongeka kwa machiritso a fracture komanso kuchepa kwa mafupa. 

Ngakhale kuti anthu ambiri amawaona ngati “matenda a amayi”, amatha kugwira aliyense ndipo 20 peresenti ya omwe ali ndi matendawa ndi amuna. Pali zinthu zomwe zimachulukitsa chiopsezo koma ndikofunikira kuti aliyense adziwe zizindikiro. 

Osteoporosis imayamba pang'onopang'ono pakapita zaka zambiri. Mkhalidwe uwu wa thanzi, mafupa amafooka zomwe zimawapangitsa kukhala osalimba komanso pachiwopsezo chothyoka. Nthawi zambiri zimangodziwika pamene kugunda kwadzidzidzi kapena kugwa pang'ono kumayambitsa kusweka kwa fupa. 

Kuvulala kofala kwambiri kwa anthu omwe amapezeka kuti ali ndi kufooka kwa mafupa ndi awa:

• Hip fractures
• Kuphulika kwa dzanja
• Mafupa a msana (mafupa a msana) 

Komabe, kuvulala kumatha kuchitikanso m'mafupa ena, monga m'chiuno kapena mkono. Nthawi zina, kuyetsemula kapena chifuwa kungayambitsenso kuthyoka kwa nthiti kapena kugwa pang'ono kwa fupa la msana. 

Osteoporosis imakhudza anthu opitilira 3 miliyoni ku United Kingdom kokha. Chaka chilichonse, anthu opitilira 500,000 amalandila chithandizo chamankhwala akulephera kufooka chifukwa cha kufooka kwa mafupa. 

 

Monga tanenera kale, aliyense akhoza kudwala matenda osteoporosis. Komabe, pali zinthu zina zomwe zimawonjezera ngozi:

• Low body mass index (BMI);
• Mbiri ya banja la osteoporosis;
• Kumwa mowa kwambiri ndi kusuta fodya;
• Kugwiritsa ntchito nthawi yayitali kapena kugwiritsa ntchito molakwika oral corticosteroids;
• Zochitika zachipatala monga zovuta za malabsorption, matenda otupa, kapena zokhudzana ndi mahomoni
• Kugwiritsa ntchito nthawi yayitali mankhwala enaake omwe angakhudze kuchuluka kwa mahomoni kapena mphamvu ya mafupa. 

Mikhalidwe, Matenda, ndi Njira Zachipatala Zomwe Zingayambitse Kutaya Mafupa 

Pali njira zingapo zamankhwala ndi zina zambiri zaumoyo zomwe zingapangitsenso mwayi wa osteoporosis. 

Mndandandawu ungaphatikizepo, koma osalekezera ku:

• Matenda a nyamakazi (RA);
• Matenda angapo ofoola ziwalo;
• Gastrectomy;
• Ankylosing spondylitis;
• Njira zodutsa m'mimba;
• Matenda opweteka a m'mimba (IBD);
• Opaleshoni kuwonda;
• Leukemia ndi lymphoma;
• Sickle cell matenda;
• Thalassemia;
• Kupsinjika maganizo ndi kusokonezeka kwa zakudya;
• Kutsika kwa testosterone ndi estrogen mwa amuna;
• Kusiya kusamba msanga kapena kusakhazikika kwanthawi zonse;
• Kusadya bwino, kuphatikizapo kuperewera kwa zakudya m’thupi;
• Matenda osokoneza bongo (COPD), kuphatikizapo emphysema;
• Matenda a impso;
• Hyperthyroidism ndi hyperthyroidism. 

Ostarine ndi Osteoporosis: Zingathandize Bwanji?

Amuna ndi akazi onse amakumana ndi chiwopsezo chowonjezereka cha zovuta zaumoyo akamakalamba, popeza mahomoni oteteza mafupa ogonana amachepetsa pakapita nthawi. Izi zimawonjezera chiopsezo cha kufooka kwa mafupa ndi kudwala matenda a mafupa. 

Osteoporosis, komanso matenda ena a mafupa, amatha kukhudza kwambiri moyo wa tsiku ndi tsiku wa munthu. Mphamvu zawo zakuthupi zitha kukhala zochepa, ndipo zotulukapo zake zimakhala zowawa. Anthu amene ali ndi vutoli angadzipeze kuti sangathe kuchita zinthu zimene ankatha kuchita poyamba. Atha kukhala ndi zovuta zokhudzana ndi thanzi lawo lamaganizidwe chifukwa cha zowawa, kuopa kudzivulaza okha, kapena kulepheretsa zochita zawo zatsiku ndi tsiku.

Akadziwika, matenda a mafupa amatha kuchiritsidwa, koma kuchira kwathunthu sikutheka. Zimayang'ana kwambiri kulimbikitsa mafupa, kusunga moyo wabwino, komanso kupewa kuvulala kwina. 

Chifukwa chake, kupewa ndi sitepe yofunika kwambiri. Zina mwa njira zabwino zolimbikitsira mafupa anu ndi awa: 

Kupeza ma calcium okwanira ndi vitamini D: Zakudya zopatsa thanzi nthawi zambiri zimakhala zokwanira pakudya kovomerezeka. Komabe, amathanso kutengedwa ngati zowonjezera.

Magwero a calcium ndi awa: mkaka, tchizi ndi mkaka; masamba obiriwira (kupatula sipinachi); ndi nsomba m’mene mumadyera mafupa (monga sardine). 

Zakudya zambiri za mkaka monga soya, oat, ndi amondi zili ndi calcium ndi vitamini D wowonjezera. Vitamini D amapezeka mu nsomba zamafuta ambiri, nyama yofiira, ndi yolk ya dzira. Zakudya zina zam'mawa ndi zofalitsa zopanda mkaka zimalimbikitsidwanso ndi vitamini D. 

Kuchita masewera olimbitsa thupi: Kuchita masewera olimbitsa thupi nthawi zonse kumathandiza kuti mafupa agwire ntchito. Mofanana ndi minofu, imamanga ndikusunga mphamvu zawo pakapita nthawi. 

Kupeza mapuloteni okwanira: Mapuloteni ndi gawo lina lazakudya zanu zomwe zimathandizira kuti mafupa akhale athanzi. Othamanga ambiri akudziwa kale kuti amadya mapuloteni - koma apa pali chifukwa chinanso chomwe chili chofunikira. Mungapeze mapuloteni mu: nyama zowonda ndi nkhuku; mazira; mtedza, nyemba, ndi nyemba; ndi mkaka wopanda mafuta ochepa. Mapuloteni ufa ndi kugwedeza akukhala otchuka kwambiri kuti awonjezere kudya mapuloteni, nawonso. 

Kukhalabe ndi thanzi labwino: Low body mass index (BMI) ndi chiwopsezo cha mafupa osweka, monga momwe zimakhalira kusinthasintha kwadzidzidzi kwa kulemera kwa munthu. Ngakhale mutakhala mukudula, ndikofunikira kudya zopatsa mphamvu zokwanira kuti thupi lanu ndi malingaliro anu azitha kudzisamalira. Ena kafukufuku asonyeza kuti kuondanso pambuyo pochepa kwambiri sikuchepetsa chiwopsezo cha kuchuluka kwa mafupa. 

Chiwopsezo cha kusweka kwa fupa chikhoza kuchepetsedwa powonjezera minofu ndi mafupa a mineralization. Apa ndi pamene Ostarine ndi matenda osteoporosis amabwera pachithunzipa. 

Ostarine ikhoza kupititsa patsogolo mphamvu ya mafupa, komanso kulimbikitsa chigoba chonse. Testosterone yotsika ndi imodzi mwazinthu zowopsa zomwe zadziwika pamndandanda womwe uli pamwambapa. Potengera zotsatira za testosterone m'mafupa ndi minofu, Ostarine imathandiza kupewa matenda a mafupa. 

Malinga ndi kafukufuku, MK-2866 imawonetsa zotsatira zopindulitsa pamafupa, magwiridwe antchito amthupi, komanso kuwonongeka kwa minofu. Chifukwa cha maulalo awa, amalemekezedwa chifukwa cha kuthekera kwake kulimbikitsa machiritso ovulala ndikufulumizitsa nthawi yochira. Tili ndi positi yosiyana yabulogu pa izi, yomwe mutha kuwerenga Pano. 

Kafukufuku wa Zamankhwala pa Ostarine Bone Healing 

Ostarine ndi osteoporosis sizinaphunzirepo kwa nthawi yayitali kuti ziwone zotsatira za kugwiritsidwa ntchito kwa zaka makumi ambiri - kotero ndikofunikira kulingalira kuti zotsatira za nthawi yayitali zimakhala zosatsimikizika. Komabe, kafukufuku wamankhwala ali mkati. Koposa zonse ndi lingaliro lakuti Ostarine ndi yothandiza kupititsa patsogolo kachulukidwe ka mafupa ndi kuchiritsa fupa: 

Kafukufuku wina anaphunzira za postmenopausal osteoporotic bone mu rat osteoporosis model. Pa nthawi yophunzira, an ovariectomy adachitidwa ndi 46 mwa makoswe a 56 a miyezi itatu ya Sprague-Dawley.

Ostarine ankaperekedwa pamlomo tsiku ndi tsiku masabata asanu ndi atatu pambuyo pa ovariectomy mu mlingo wa 0.04 (otsika, OVX + Ost. 0.04), 0.4 (wapakatikati, OVX + Ost 0.4), ndi 4mg / kg (mkulu, OVX + Ost. 4) thupi. kulemera.

Gulu lina la makoswe a ovariectomised sanalandire Ostarine monga ulamuliro. Zotsatira za Mlingo wapakatikati ndi waukulu zidafaniziridwa ponse. 

Makamaka, kusintha kunkawoneka muzinthu zamapangidwe monga kuchuluka kwa mafupa a mafupa ndi kachulukidwe ka mafupa a mafupa. Kafukufukuyu adawonetsanso kuti chithandizo chachifupi cha mafupa a osteoporotic ndi MK-2866 chingapangitse kusintha kwa ma microstructural bone indices. Ofufuzawo adanena kuti chithandizo cha nthawi yayitali cha Ostarine chochiza mafupa amatha kupititsa patsogolo katundu wa biomechanical. 

 

Kodi Chinanso Ndingayembekezere Chiyani?

Ostarine imakondweretsedwa chifukwa cha kupita patsogolo kwake pochiza kuchepa kwa mafupa. Komabe, palinso zopindulitsa zina zomwe zingawasiye ogwiritsa ntchito kukhala amphamvu komanso okonzeka kusintha thupi lawo. 

Chimodzi mwazabwino zazikulu za Ostarine chifukwa cha kuchuluka kwa mafupa ndikuti zotsatira zomwe zapezedwa nazo ndizosavuta kuzisunga. Uwu ndi mwayi wodabwitsa komanso wofunikira kwambiri kuposa zotsatira zake zowoneka bwino komanso zazikulu zokulitsa minofu. Mwachiwonekere, palibe chodetsa nkhaŵa kwambiri kwa othamanga ndi omanga thupi kusiyana ndi kutaya minofu yonse yomwe inapezedwa (pangopita nthawi yochepa) pambuyo pa miyezi ndi zaka zogwira ntchito mwakhama. 

Ogwiritsa ntchito Ostarine amatha kuyembekezera kulandira zabwino, zowuma, komanso zopindulitsa zomwe zimadziwika ndi kuchuluka kwa mapuloteni. Monga Selective Androgen Receptor Modulator, Ostarine imamangiriza ku ma androgen receptors mu minofu ndi mafupa. 

Izi zimayambitsa kuwonjezeka kwa osteo- ndi myo-selective anabolic ntchito. Potsirizira pake, kusintha kumeneku kumalimbikitsa kaphatikizidwe ka mapuloteni a minofu (MPS), njira ya thupi yomwe imayambitsa kuwonjezeka kwa kukula kwa minofu.  

Mapindu a mafupa a Ostarine ndi ofunika kwambiri poganizira za thanzi lalitali. Komabe, kuphatikiza apo, Ostabolic imathanso kupititsa patsogolo kulimba, kukweza kupirira, komanso kulimbikitsa mphamvu. 

Koposa zonse, kugwiritsa ntchito Ostarine panthawi ya ma SARM sikukugwirizana ndi kuwonongeka kwapambuyo. 

Chonde dziwani kuti Ostarine iyenera kugwiritsidwa ntchito mkati mwa malangizo azamalamulo. Pakali pano sikuvomerezedwa ndi American Food & Drug Administration. Tikukulimbikitsani kuti muchite kafukufuku wanu musanaganizire za SARM za kuchulukira kwa mafupa, ndi muyenera kuchigwiritsa ntchito motsogozedwa ndi dokotala. 

Kulankhula ndi katswiri wa zachipatala sikungokuthandizani kuti mukhalebe m'malamulo a dziko lanu, koma zidzakutetezani momwe mungathere. Thanzi lanu ndilofunika kwambiri kuposa china chilichonse, komabe muli ndi mwayi wopeza mphamvu zathanzi komanso zopambana. 

Ngati muli ndi mafunso, Masitolo a SAR ku UK ndi wokondwa kuyankha! Chifukwa cha malamulo osiyanasiyana padziko lonse lapansi, sitingathe kupereka uphungu wogwirizana ndi ma SARM - izi ndi za dokotala wanu. Komabe, timakonda kumva kuchokera kwa inu ndikucheza kudzera muzofunsa zanu.