YK-11
YK-11, wotchedwanso Myostine, adavoteledwa kwambiri ndi akatswiri olimbitsa thupi komanso othamanga mwamphamvu padziko lonse lapansi. Izi zopangidwa ndi steroidal zosankha androgen receptor modulator (SARM) ili ndi zochitika zofanana ndi za anabolic zomwe ndizofanana ndi anabolic androgenic steroids mwachilengedwe.
YK-11 idaphunziridwa koyamba mu 2011 ndi wofufuza waku Japan Yuichiro Kanno. Anapezeka kuti ndi agonist pang'ono wa receptor ya androgen yokhala ndi machitidwe osankha majini. Kafukufuku wakale anenapo kuti YK-11 ali ndi zotsatira zabwino zomanga minofu kuposa Dihydrotestosterone (DHT). Ili ndi chizoloŵezi chokhala ngati Myostatin inhibitor.
Kodi Myostatin Inhibitor Ndi Chiyani?
Myostatin (yomwe imadziwikanso kuti kukula kosiyanitsa chinthu 8) ndi protein yomwe imatulutsidwa ndikutulutsidwa ndi myocyte (mtundu wamaselo omwe amapezeka muminyewa yaminyewa) yomwe imagwira ntchito yama autocrine yama cell a minofu kuti muchepetse myogenesis: kukula ndi kusiyanitsa kwa cell cell.
Kwenikweni, Myostatin amalepheretsa thupi kukula minofu yambiri. Myostatin inhibitor ngati YK-11 imalepheretsa kuchuluka kwa Myostatin mthupi ndipo izi zimakupatsani mwayi wopitilira kumanga kwanu kwa minofu ndi zolimbitsa thupi. Kuphatikiza pa izi, YK-11 imathanso kukulitsa Follistatin, puloteni yolimbitsa thupi, pamlingo waukulu. Mwanjira ina, YK-11 imathandizira thupi kupanga zopindulitsa zazikulu kutengera minofu yolimba yomwe ikadakhala yosatheka.
Momwe YK-11 imagwirira ntchito?
YK-11 imadziphatika ku cholandilira cha androgen chomwe chimalimbikitsa ma cell amisempha kuti apange mwachilengedwe zinthu zambiri za anabolic. Mosiyana ndi ma SAR ambiri, YK-11 siyimabwera ndi zotsatira zochepa za androgenic ndipo imabweretsa kukula kwakukulu kwa minofu. Kuphatikiza pa maubwino awa, YK-11 imalimbikitsanso kusungidwa kwa minofu, kukula kwa minofu, ndikukula kwa maselo amtundu watsopano.
Agonist wosankha jini wa receptor ya androgen amadziwika bwino chifukwa cha kuthekera kwake kosakulitsa kulumikizana kwamtundu uliwonse pakati pa NTD / AF1 ndi LBD / AF2 [N-terminal domain (NTD) ndi activation function (AF); AF1 ndi AF2 zili mkati mwa NTD ndi domain yolumikizana ndi ligand (LBD) ndikuwongolera zochitika zolembedwa za estrogen receptor (ER)] zomwe zimafunikira pakuwongolera kwathunthu kwa wolandila a androgen. YK-11 ikuwonetsa zochitika za anabolic mu vitro mu C2C12 myoblasts ndipo imapereka potency yabwino poyerekeza ndi dihydrotestosterone (DHT) munthawi imeneyi.
Chifukwa chake, imakhala njira yabwino kwa aliyense amene akufuna kusinthana ndi anabolic steroids omwe nthawi zambiri amakhala abodza, ochepa, ndipo amathandizanso pazovuta zina. YK-11 ndichinthu chodabwitsa kwa anthu omwe ali ndi chidwi chofuna kulimbitsa thupi omwe akufuna kukhala ndi minofu yolimba komanso kutalikirana ndi mafuta.
YK-11 Ndipo Testosterone-Kuyerekeza
Testosterone ndi mahomoni ovuta omwe amapezeka mthupi la munthu. Zimagwira ntchito ngati anabolic steroid komanso mahomoni ogonana.
YK-11 ndi Testosterone ndizofanana mofananira ndi magwiridwe antchito. Chokhacho chomwe chimasiyanitsa ndikuti YK-11 imapangidwa kuti ingoyang'ana pa maselo ena pomwe Testosterone imagwira ntchito m'maselo ambiri mthupi la munthu. Ndikofunikira kudziwa apa kuti Chilichonse choposa milingo yachilengedwe m'magazi chimatha kuyambitsa zovuta zina monga kukulitsa kwa prostate. Mwanjira ina, kugwiritsa ntchito jakisoni wa testosterone kapena jakisoni wa testosterone kwa nthawi yayitali sikulimbikitsidwapo chifukwa maubwino ake amapitilira ndi zoyipa, makamaka pomwe testosterone imaperekedwa kwambiri.
YK-11 imagwiranso ntchito kumatenda amtundu wokha chifukwa chake zotulukapo zake zimakhala zero kapena zochepa. Kuphatikiza apo, YK-11 itha kuperekedwa m'njira yamlomo yomwe imakhala yotetezeka komanso yosavuta poyerekeza ndi jakisoni wa testosterone yemwe angapangitse kuti apange malekezero, kugawana masingano, ndi kupweteka m'malo opangira jekeseni.
Ubwino Wa YK-11
Chimodzi mwamaubwino akulu kwambiri a YK-11 ndikuti zimathandizira kukulitsa minofu yatsopano kuposa omwe afika kale pamlingo wazibadwa. Izi, zimathandizanso kuwonjezeka kwa msana wa corset ndi kuuma.
Zimatanthauzanso kuti thupi lolemera la thupi silimatha kutopa kapena kusokonekera ngakhale panthawi yophunzitsidwa ndi mtima komanso kulimbitsa thupi kwambiri. Zotsatira zake, kulimbitsa thupi ndi magawo a maphunziro azikhala aatali komanso ogwira ntchito komanso amphamvu. Izi ziwonetsetsanso kuti zotsatira zomwe zapezeka zitha kusungidwa mosavuta nthawi yayitali YK-11 itatha.
Kugwiritsa ntchito YK-11 kumalumikizidwanso ndi maubwino akulu, kuphatikiza koma osawerengera:
- Palibe anabolic steroid zotsatira
- Imathandizira kulimba kwa minofu
- Kuletsa Myostatin
- Zowonjezera m'magulu a Follistatin
- Mapampu abwinoko ndikuwonjezeka kwamafuta
- Wonjezerani mphamvu zamphamvu ndi kukula
- Kutsamira kwa minofu kupindulira popanda kusungira madzi
- Imachedwetsa ukalamba wamaselo
- Kupititsa patsogolo magazi
- Kuwonjezera chipiriro
- Imalimbikitsa kuyaka mafuta
- Amakuthandizani kuti muchotse mafuta am'mimba komanso owoneka bwino
- Zimalepheretsa kuchepa kwa minofu panthawi yochepetsa thupi
- Zimalepheretsa kuwonongeka kwa mitsempha
- Zimalimbikitsa kukula kwa minofu yayikulu popanda chododometsa
- YK-11 imatha kuwonjezedwa pamitundu yonse yazowonjezera mphamvu ndikukula kwa minofu
Malangizo a YK-11
Mlingo woyenera wa YK-11 ndi 2-5mg (ya akazi) kawiri ndi 5-10mg kawiri patsiku (kwa amuna), makamaka ndi chakudya, kwa masabata a 6-8. Ogwiritsa ntchito amuna amathandizanso kuwonjezera mlingo wa YK-11 mpaka 20mg patsiku pakadutsa steroid kapena ma SAR ma cycle ndi YK-11 ngakhale zili bwino nthawi zonse kuyamba kugwiritsa ntchito YK-11 pamlingo wochepa m'magawo oyamba ndikupeza malo ako okoma. Kuzungulira ndi YK-11 kumayenera kutha nthawi zonse ndi mankhwala ozungulira pambuyo pake kuti mukhale otetezedwa ndikusunga zopindulitsa zopangidwa ndi SARM yabwinoyi.
Theka-Moyo Wa YK-11-Malangizo ndi Zomwe Mungachite
YK-11, monga ma SAR ambiri, si hepatotoxic popeza si methylated. Kuphatikiza apo, amadziwika ndi kuchuluka kwa bioavailability wamkamwa zomwe zikutanthauza kuti YK-11 imatha kulowetsedwa m'malo mojambulidwa. Hafu ya moyo wa YK-11 pafupifupi maola 5-8.
Ndikofunika kuzindikira kuti YK-11 siyikulimbikitsidwa kwa amayi apakati ndi oyamwitsa. YK-11 salangizidwanso kwa anthu omwe ali ndi matupi awo sagwirizana ndi zinthu zomwe sizigwira ntchito. Kuphatikiza apo, kugwiritsidwa ntchito kwa YK-11 kumayenera kuchitika nthawi zonse ndikungogwiritsidwa ntchito mwalamulo moyang'aniridwa ndi azachipatala. Mlingo wa YK-11 sayenera kuwonjezeka popanda chitsogozo chachipatala chisanachitike.
Zinthu Zosungira YK-11
YK-11 imasungidwa bwino m'malo amdima komanso ozizira, omwe amakhala kutali ndi dzuwa, kutentha, ndi chinyezi. Amasungidwa bwino kutentha kwapakati pa 0 - 4 madigiri Celsius kwakanthawi kochepa (masiku mpaka masabata) kapena -20 madigiri Celsius kwanthawi yayitali (miyezi mpaka zaka), pokhapokha zitanenedwa.
YK-11 Kuwonongeka
Kuti zitheke bwino, omanga thupi ndi ma powerlifters amaika YK-11 ndi Ibutamoren (MK-677). Kuphatikiza kwa MK-677 ndi YK-11 kumapangitsa malo abwino kukhala olimba mphamvu, minofu, kukula kwa minofu, komanso kupindula kwa kukula kwa minofu. YK-11 imaphatikizidwanso ndi Mayeso (RAD-140) chifukwa chokumana ndi kusintha kwamphamvu kwa thupi.
YK-11 imaphatikizidwanso ndi Ligandrol (LGD-4033) yomwe imadziwika bwino chifukwa chopeza phindu lalikulu la minofu. Ngati mukukonzekera RAD-140 ndi YK-11 mkati mwa masabata 6-8, RAD-140 imagwiritsidwa bwino ntchito muyezo wa 15-30mg limodzi ndi 10mg ya YK-11 tsiku lililonse. Mbali inayi, malo abwino a LGD-4033 ndi YK-11 amatha bwino ndi 10-15mg ya LGD tsiku lililonse komanso 5-10mg ya YK-11 tsiku lililonse.
YK-11 Zotsatira
Zotsatira ndi YK-11 ndizodabwitsa kwambiri, kungonena zochepa. Izi ndichifukwa choti zili ndi zotsatira za anabolic pamafupa ndi minofu. Nzosadabwitsa kuti YK-11 imawonedwa ndi akatswiri amakampani ndi ogwiritsa ntchito ngati SARM yamphamvu kwambiri yomwe ilipo.
Kugwiritsa ntchito YK-11, mukakwaniritsa chakudya chabwino komanso kulimbitsa thupi kwambiri, kungakuthandizeni kunyamula mosavuta ma 10lbs a minofu yabwino mkati mwa milungu 6-8. Kupeza minofu kotereku munthawi yochepa kumatenga zaka kuti zifike mwachilengedwe. Ndemanga za pa intaneti za YK-11 zingakuthandizeni kuzindikira zabwino zenizeni za YK-11. Ogwiritsa ntchito ambiri amafotokoza zomwe sizinachitikepo komanso misala yamphamvu ndikupeza mphamvu pamene akufufuza ndi YK-11.
Momwe Mungagulire YK-11 Paintaneti-YK-11 Kuti Mugulitse
YK-11 ingagulidwe mosavuta pa intaneti pogwiritsa ntchito njira zotetezera zotetezeka. Komabe, muyenera kuwonetsetsa chisamaliro komanso khama nthawi zonse mukamagula popeza pali opanga onyenga ambiri a YK-11 pa intaneti. Kugula kudzera mwa iwo sikutanthauza kuti mudzataya ndalama zomwe mwapeza movutikira, komanso kungatanthauzenso kuti mukugwiritsa ntchito zabodza kapena zochepera kapena zochepa za YK-11 zomwe zitha kubweretsa zovuta zoyipa.
Chifukwa chake, nthawi zonse amalangizidwa kuti mugule YK-11 pa intaneti kokha kuchokera kwaogulitsa ma SARM ngati Masitolo a SARM yomwe imagwira ntchito yoyamba yokha, YK-11 yopanga kafukufuku.