Yohimbine
Yohimbine, alpha-2 adrenergic receptor antagonist, ndi chimodzi mwazinthu zodziwika bwino popangira masewera olimbitsa thupi, mafuta owotchera mafuta, komanso zowonjezera zakudya. Zowonjezera za Yohimbine zimagwiritsidwa ntchito pazinthu zosiyanasiyana, kuphatikiza koma zochepa pakulimbikitsa kuchepa kwa thupi ndikuchiza kuwonongeka kwa erectile (ED). Yohimbine imagwiranso ntchito kuthana ndi mavuto azakugonana omwe amadza chifukwa cha mankhwala opsinjika mtima omwe amatchedwa selective-serotonin reuptake inhibitors (SSRIs). Amagwiritsidwanso ntchito ndi othamanga komanso omanga thupi kuti apititse patsogolo magwiridwe antchito ndipo Yohimbine amadziwikanso kuti amachepetsa mantha okhudzana ndi ma phobias ena.
Njira Yogwirira Ntchito Ya Yohimbine
Yohimbine imaletsa alpha-1 ndi alpha-2 adrenoceptors, imachepetsa kuchuluka kwa serotonin, ndikuwonjezera kuchuluka kwa dopamine ndi adrenaline. Amadziwikanso kuti amachepetsa shuga m'magazi, amatulutsa insulin, komanso amachulukitsa kuthamanga kwa magazi. Zimayambitsa kuchepa kwa mitsempha yamagazi ndikutulutsa kwatsopano pamatumbo akumaliseche. Yohimbine imadziwikanso kuti imathandizira kukonzanso kosakhazikika m'chigawo cha sacral cha msana. Zonsezi ndizodziwika bwino chifukwa chotseka kwa serotonin receptor, blocking calcium channel, ndi monoamine oxidase inhibiting zotsatira.
Yohimbine amaletsa presynaptic alpha-2 adrenergic receptors kwambiri pamizere ya Reserpine ngakhale zochita zake zimakhala zazifupi komanso zofooka. Mphamvu yodziyimira payokha yamphamvu ya Yohimbine ndikuchepetsa kumvera chisoni (adrenergic) ndikuwonjezera zochitika za parasympathetic (cholinergic). Ndikofunikira kukumbukira pano kuti kukonzekera kugona amuna kumalumikizidwa ndi zochitika za cholinergic komanso alpha-2 adrenergic blockade yomwe ingapangitse kuchepa kapena kuchulukitsa kwa penile, kapena zonse ziwiri.
Kuchotsa malo osungira mafuta osakanikirana ndi zakudya zanu nthawi zambiri kumakhala kovuta chifukwa cha zifukwa zingapo. Palibe chodabwitsa kuti ambiri a ife timapeza kuti ali ndi malo ena omwe "ali ouma khosi" kapena samasiya mosavuta mafuta oyipa [nthawi zambiri amakhala otsika, kumbuyo kumbuyo, ndi m'chiuno kwa amuna ndi miyendo ndi chiuno cha akazi]. Nthawi zambiri, izi zimachitika chifukwa cha kuchuluka kwa olandila a Alpha-2 m'maselo amafuta omwe amauza thupi kuti ligwiritse mafuta m'malo amenewa kuti apulumuke. Yohimbine amalepheretsa olandila awa a Alpha-2 motero amapha uthengawo kuti asunge mafuta ouma khosi amenewo. Imamasulanso mafuta kuti asungunuke (kuyaka).
Kuyanjana kwa Enzymatic
Yohimbine amatha kuyanjana ndi CYP2D6 enzyme ndikuletsa magwiridwe ake. Kafukufuku woyesa Ki adazindikira Ki yodziwika ya 0.52uM yama enzymes a CYP2D6 oyeretsedwa ndi 0.23uM yama microsomes. Izi zimafikira ku Corynanthine wokhala ndi Ki ya 0.08uM. Ndikofunikira kudziwa apa kuti iyi ndi enzyme yomweyi yomwe imagwiritsa ntchito Yohimbine kukhala 11-hydroxy Yohimbine ndikuwonetsa kusiyanasiyana pakati pa anthu 1000 kutengera mtundu wa CYP2D6 (osalumikizana pang'ono ndi CYP3A4).
Ubwino Wa Yohimbine
- Yohimbine imathandizira kuthana ndi zikhumbo zosafunikira.
- Zimathandiza kulimbana ndi mafuta amakani am'mimba.
- Yohimbine imachepetsa kuchuluka kwamafuta popanda kuwononga misala yowonda yomwe ndiyofunika kwambiri pakukhathamiritsa thupi.
- Zimathandizira kuchita masewera olimbitsa thupi poletsa kutopa kwakuthupi komwe ndi chinthu chabwino chifukwa choti kulimbitsa thupi kumatha kuchepetsedwa chifukwa chakuchepa kwa kalori.
- Yohimbine imathandizira kagayidwe kabwino kazomwe zimayaka mafuta.
- Zimasintha kwambiri kupirira ndi mphamvu.
- Yohimbine ndi wachiwiri kwa wina chifukwa chowotcha mkono wamakani, ma handles achikondi, ma glute (mbuyo), ndi mafuta aku ntchafu.
- Yohimbine imagwira ntchito bwino ngati choletsa chilakolako chofuna kudya.
- Mphamvu zolimbikitsa modabwitsa za Yohimbine zimapanga chisankho chabwino kwa othamanga, kutuluka kapena kutuluka panja.
- Osati izi zokha, Yohimbine amachulukitsa kwambiri magawo okhutira okhutira, kulakalaka, kugwiranagwiranso pafupipafupi, komanso kusintha kwa machitidwe ogonana.
- Zimathandizanso kuchepetsa ziwonetsero zakuthupi ndi zamaganizidwe zomwe nthawi zambiri zimakhudzana ndi kukanika kwa erectile.
Kutulutsa magazi kwa Adrenergic
Makina ofufuzidwa kwambiri komanso oyambira a Yohimbine ndikosakhazikika (antagonism) kwamagulu amalandiridwe otchedwa Alpha-2-Adrenergic receptors. Yohimbine imalepheretsa ma autoreceoptors awa pa presynaptic noradrenergic neurons kuti achulukitse kutulutsidwa kwa noradrenaline chifukwa cholakwika cha mayendedwe olakwika chimasokonezeka.
Yohimbine Ndi Kutha Kutha
Yohimbine ali ndi kuthekera kopangitsa kutha kwa mantha komwe kumachitika mwamaganizidwe pomwe kuwonekera kosalekeza koyambitsa mantha nthawi zambiri kumayambitsa kukhumudwa kuzomwe zimapangitsa komanso kuchepetsa kapena kuthetsa mantha omwe amakhala nawo. Pachifukwa ichi Yohimbine amalumikizidwa ndi kutha kwamantha kwachiwiri kuchipatala.
Yohimbine Ndi Kutayika Kwamafuta
Yohimbine imagwiritsa ntchito adrenergic receptor system yamafuta amthupi omwe amayang'anira thermogenesis. Ma beta-subunits a adrenergic receptors, omwe ndi zolinga za ephedrine, amawoneka ngati othandizira kutaya mafuta chifukwa amathandizira ntchito ya Adenyl Cyclase (enzyme) kenako Cyclic adenosine monophosphate [(chochokera ku milingo ya adenosine triphosphate (ATP)] .
Ndikofunikira kukumbukira apa kuti ma alpha-subunits amapondereza kwambiri mafuta. Yohimbine, pokhala wotsutsana ndi alpha-2 adrenergic receptor antagonist (inactivator), amalepheretsa kuyambitsa kwa ma receptor opondereza ndikusunga zochitika za Adenyl Cyclase ndi zotsatira zoyimira pakati pa omwe amalandila beta.
Momwe Mungatengere Yohimbine?
Nthawi zambiri, Yohimbine imagwiritsidwa ntchito bwino pamankhwala a tsiku ndi tsiku a 0.2 mg pa kilogalamu ya thupi kuti uwotche mafuta. Izi zitanthauza kuchuluka kwa 14mg kwa munthu wa 150lb kapena 18 mg wa q 200lb payekha. Ndikofunikira kudziwa apa kuti Yohimbine supplementation imagwira ntchito kwambiri pakusala kwakanthawi kochepa kapena pakati pa chakudya. Ngati mukukayikira kapena kusokonezeka pamalingaliro oyenerera a Yohimbine, ndibwino kuti nthawi zonse muzikhala ndi mawu ndi dokotala kapena pharmacy wapafupi m'malo motenga zolakwika za Yohimbine.
Momwemo, Yohimbine imayendetsedwa bwino asanasala kudya kwa mtima. Insulin imasokoneza zotsatira za Yohimbine pa Alandira-2 Receptors. Chifukwa chake, kudya pafupi ndikugwiritsa ntchito Yohimbine sikungakhale kopindulitsa ndipo nthawi zonse kumakhala bwino kusala kudya kwa maola osachepera 3-4 musanagwiritse ntchito Yohimbine. Chachiwiri, mafuta amafunika kuti awotchedwe olandila a Alpha-2 atatsekedwa. Izi zikutanthauza kuti thupi liyenera kukhala likuchita zochitika zina ndipo palibe chochita china chabwino kuposa kusala kudya kwa mtima.
Kuwononga Yohimbine
Yohimbine itha kuphatikizidwa ndi Selective androgen receptor modulators ngati Ostarine(MK-2866), Ibutamoren(MK-677), Andarine(S-4), LGD-4033ndipo Cardarine(GW-501516).
Katundu wa GW-501516 ndi Yohimbine ndiopambana m'njira zambiri. Cardarine ndiwofunika kwambiri kuti mulowe mukulimbitsa thupi ndikuwongolera kupirira. Ndizofunikanso kuthana ndi vuto lakukhala otopa panthawi yolimbitsa thupi kwambiri chifukwa chokhala ndi ma cardio ochepa komanso ma carbs ochepa. Mwanjira ina, Cardarine amakuthandizani kuti muzichita mobwerezabwereza ndi zolemera zolemera munjira zabwino. Ngati sizokhazi, amasintha mphamvu yamagetsi yomwe imakonda kwambiri kuchokera ku shuga (chakudya) kupita kumafuta zomwe zikutanthauza kuti mudzawotcha mafuta tsiku lonse. Izi zitanthauzanso kuti padzakhala glycogen yochulukirapo yosungira zolimbitsa thupi mtsogolo. Kumbali inayi, Yohimbine ndiyodziwika kwambiri kuposa GW-501516.
Kutsutsana / Kusamala
Yohimbine imatsutsana ndi anthu omwe ali ndi mbiri yazachipatala kapena omwe akulimbana ndi zovuta zathanzi monga nkhawa, kukhumudwa, hypotension, angina, matenda a impso, kapena matenda a chiwindi. Sitikulimbikitsidwanso kuti amayi apakati kapena oyamwitsa komanso ana. Kugwiritsa ntchito Yohimbine kuyenera kupangidwa mosamala ngati mukudwala matenda ashuga, schizophrenia, matenda oopsa, kapena benign prostatic hyperplasia.
Ndikofunikira kudziwa kuti Yohimbine amawonetsa zowonjezera zowonjezera ndi monoamine oxidase inhibitors. Yohimbine imatha kuchepetsa kapena kuwonjezera kuthamanga kwa magazi ndi tricyclic antidepressants.
Mlingo wa Yohimbine sayenera kukulitsidwa kapena kuzunzidwa nthawi iliyonse ndikuyembekeza kuti zotsatira zake zichitike mwachangu. Kuzunzidwa kwa Yohimbine kumatha kubweretsa zovuta monga kuyabwa, chizungulire, komanso kusokonezeka. Kugwiritsa ntchito Yohimbine kuyenera kutsatiridwa nthawi zonse ndi kufunsira kwa akatswiri azachipatala.
Kodi Mungagule Bwanji Yohimbine?
Ngati mukufuna kuti buy Chimanga, timalimbikitsa kuti tisankhe wogulitsa yekha wotchuka wa Yohimbine ngatiMasitolo a SARM. Izi ndichifukwa choti pali ogulitsa onyenga ambiri a Yohimbine kunjaku ndipo kuwakhulupirira kungatanthauze kuti simukuwononga ndalama zomwe mumapeza movutikira, komanso kuwonetsa thupi lanu kuzinthu zabodza, zochepa, kapena zazing'ono.
Pachifukwa ichi, nthawi zonse amalimbikitsidwa kuti muwerenge ndemanga, malingaliro, malingaliro, ndi zodandaula (ngati zilipo) kuchokera kumabwalo osiyanasiyana omanga thupi ndi zina zowonjezera. Izi zikuthandizani kuzindikira omwe akugulitsa kwambiri a Yohimbine ndikusankha zowonjezera zabwino za Yohimbine kuti zigwirizane ndi zomanga thupi lanu, thanzi, komanso kulimba, zofunikira, Kuphatikiza apo, zikuthandizani kupanga chisankho chanzeru kuti mudziteteze ku zomwe zingachitike chifukwa cha nkhanza za Yohimbine. Kumbukirani, nthawi zonse kumakhala bwino kukhala otetezedwa ndikugwiritsa ntchito Yohimbine pazofunikira zanu ndizosiyananso.