Yohimbine Ndi Matsenga Pazinthu Zogulitsa Zida

Zomwe Zili Chifukwa Chomwe za Yohimbine

M'zaka zingapo zapitazi, a Yohimbine akhala akukangana pamipikisano yambiri pakati pa omwe amakhala mkati mwamakampani komanso okonda kulimba.

Ngati mukufuna mankhwala opititsa patsogolo magwiridwe antchito omwe angakuthandizeni kukhala ndi minofu yambiri komanso kutaya mafuta pochita bwino m'chipinda chogona, ndi nthawi yoti muwerenge zambiri zamankhwala osokoneza bongo omwe amadziwika kuti Yohimbine.

Yohimbine, indole alkaloid yochokera ku khungwa la Central African Yohimbe mtengo, amadziwika kuti amapereka maubwino osiyanasiyana. Imagwira ngati wotsutsa wa dopamine receptor D2, wotsutsana ndi serotonergic, komanso wotsutsana ndi alpha-adrenergic.

Pharmacology

Yohimbine itha kufotokozedwa bwino ngati indolalkylamine alkaloid yofanana ndi mankhwala kutsimikizira. Imatha kuletsa presynaptic alpha-2 adrenergic receptors. Mphamvu yodziyimira payokha yamphamvu ya Yohimbine ndikuchepetsa kumvera chisoni (adrenergic) ndikuwonjezera zochitika za parasympathetic (cholinergic).

Yohimbine imadziwikanso kuti imalepheretsa alpha-1 ndi alpha-2 adrenoceptors. Pochita izi, zimalimbikitsa kuchuluka kwa adrenaline ndi dopamine ndikuchepetsa ma serotonin. Izi, zimathandizanso kutulutsa kwa insulin komanso kuchepetsa shuga m'magazi. Mankhwalawa amadziwikanso kuti amaletsa dopamine-2 ndi dopamine-3 (D2 ndi D3) receptors ndi serotonin-1B, -1D, -2A, and -2B (5-HT1B, 5-HT1D, 5-HT2A, and 5- HT2B) zolandila.

Ndikofunikira kudziwa apa kuti kukwera muzochita zogonana amuna kumalumikizidwa ndi zochitika za cholinergic komanso alpha-2 adrenergic blockade yomwe imapangitsa kuti pakhale kuwonjezeka kapena kuchepa kwa penile. Yohimbine imathandizira kwambiri kuthekera kwa erectile popanga kuwonjezeka kwakukulu pagalimoto yachifundo yachiwiri mpaka kutulutsidwa ku norepinephrine. Lilinso ndi kuthekera kulimbikitsa kuchuluka kwa maselo mu noradrenergic mtima za ubongo.

Yohimbine Ndi Kutayika Kwamafuta

Yohimbine ndiwotchuka kwambiri kwa othamanga komanso omanga thupi panthawi yazocheka za SARM chifukwa chakutha kwake ngati mankhwala ochepetsa thupi.

Alpha-2 zolandilira ndizofala pamasamba amthupi omwe amakhala ndi mafuta mosakondera: ntchafu, mawere, pamimba, ndi matako. Malo olandirira a Alpha-2 akawonetsedwa ku catecholamines monga epinephrine ndi norepinephrine amaletsa kutulutsa mafuta acids (lipolysis) pomwe zolandilira za beta zimalimbikitsa lipolysis.

Kwenikweni, kutulutsa mafuta acid kuchokera ku adipose minofu kulowa m'magazi kumalimbikitsidwa ndi glucagon, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine, ndi hormone yakukula. Mafuta amchere kamodzi m'magazi nthawi zambiri amakhala okosijeni ngati mafuta amchere am'magazi samakwezedwa kuchokera pamafuta amafuta omwe amachitika ndikudya.

Nthawi zambiri, mafuta amchere m'magazi amakonda kusungira mafuta akakhala kuti amadza chifukwa chosachita komanso kudya mopitirira muyeso. Polankhula mwachiphamaso, kuletsa ma alpha-2 receptors kumakhala kothandiza pakumasula ma catecholamines monga norepinephrine panthawi yolemetsa komwe kumapangitsa kuti ikhale yopezeka yolimbikitsira masamba a beta omwe amadzetsa lipolysis. Yohimbine kudzera mu alpha 2-adrenergic receptor antagonist zochita zake zimakulitsa milingo ya norepinephrine m'magazi.

Ntchito Zamankhwala Za Yohimbine

Yohimbine imagwira ntchito kwambiri pothana ndi kusowa mphamvu. Ichi ndi chimodzi mwazifukwa zazikulu zomwe Yohimbine amadziwikiratu kuti ndiwachisoni komanso wodabwitsa kwa odwala amuna omwe ali ndi mitsempha yam'mimba kapena yama psychogenic komanso matenda ashuga. Yohimbine amawonetsedwanso pochiza mavuto azakugonana mwa amuna ndi akazi.

Kugwiritsa ntchito Zowonjezera za Yohimbine imakhudzidwanso ndi kusintha kwakukulu pamlingo wochepetsa thupi, masewera othamanga, kuthamanga kwa magazi, komanso kutuluka kwamagazi mthupi. Amagwiritsidwanso ntchito kuthana ndi zovuta zosiyanasiyana zamatenda kuphatikiza koma osangolekezera kugona, kunenepa kwambiri, syncope, dementia, zovuta za ashuga, komanso kusowa mphamvu kwa amuna.

Yohimbine imathandizanso kuchiza matenda amukamwa owuma kapena xerostomia, thanzi lomwe limachepetsa malovu omwe amapezeka. Tiyenera kudziwa pano kuti kupanga malovu kumawonjezeka ndi Acetylcholine ndipo kumayendetsedwa ndi alpha-2-adrenoceptors. Anthu omwe amapezeka ndi xerostomia amavutika ndi kusowa kwa acetylcholine ndipo Yohimbine amawathandiza powonjezera acetylcholine.

Ubwino wonyalanyazidwa wa Yohimbine ndi kuthekera kwake kwapadera kuchitira anthu omwe ali ndi mankhwala osokoneza bongo a Clonidine, omwe ndi mankhwala omwe amagwiritsidwa ntchito pochizira Matenda odziwitsidwa / osakhudzidwa(ADHD), kuthamanga kwa magazi, kuthamanga kwa magazi, kusokonezeka kwa nkhawa, komanso zizindikiritso zakutha.

Yohimbine kuphatikiza Naloxone (mankhwala omwe amathandizira opioid overdose) amawonetsanso mphamvu yochizira Matenda a Polycystic ovary Izi ndizizindikiro zosiyanasiyana zomwe zimachitika mwa amayi omwe ali ndi mahomoni amphongo kwambiri (androgens).

Ubwino wa Yohimbine Kwa Ochita Masewera Ndi Omanga Thupi

Yohimbine imadziwikanso kuti ichepetsa mantha omwe amakhudzana ndi ma phobias ena. Pochita izi, zimathandiza othamanga ndi osewera ena kukwera mokwera komanso mwachangu ndikuzindikira zolinga zawo zomwe sizinapezeke kapena zomwe sizikanatheka kale.

Chimodzi mwamaubwino akulu a Yohimbine zikafika pakuchepa kwamafuta ndikuti amatha kuchepetsa kudya komanso kudya. Zimathandizanso kuonjezera kuwonongeka kwa mafuta musanasale kapena musanachite masewera olimbitsa thupi. Malinga ndi a phunziro, tsiku lililonse Yohimbine supplementation imatha kuchepetsa mafuta m'thupi mwa othamanga kuchokera ku 9.3 mpaka 7.1 peresenti.

Wodziwika bwino popanga zotsatira za thupi la hyperadrenergic, Yohimbine amagwiritsidwa ntchito bwino kudula magawo omwe cholinga chachikulu cha iwo othamanga komanso omanga thupi kuti apindule kapena kutanthauzira kutanthauzira kwa minofu. Yohimbine ndi mankhwala abwino kwambiri kuti ayang'ane bwino ndikumang'amba mpikisano usanachitike.

Kafukufuku wambiri wa nyama ndi anthu awonetsa kuti Yohimbine ndiyothandiza kwambiri kuthetsa mantha a zinthu zina, anthu, kapena nyama powonjezera milingo ya norepinephrine. Ichi ndiye chifukwa chake mankhwalawa amapatsidwa kwa odwala omwe ali ndi vuto la nkhawa ndipo zimawathandiza pochepetsa nkhawa komanso kukonza malingaliro.

Osati izi zokha, Yohimbine imathandizanso kukonza kukumbukira kwa nthawi yayitali pokweza milingo ya norepinephrine. Mankhwalawa akuwonetsanso kuthandizira kuwongolera magazi kutsekereza poletsa alpha-2 adrenoceptors ndikuthandizira kutembenuka kwa epinephrine kukhala norepinephrine. Makhalidwe amenewa amapangitsa Yohimbine kukhala mankhwala abwino kwambiri kwa osewera omwe amachita nawo masewera ovuta monga chess ndi masewera ena amachitidwe. Kuphatikiza apo, Yohimbine imathandizanso kukhala ndi moyo wabwino, kudzidalira, komanso kudzidalira potukula moyo wabwino.

Gulani Yohimbine tsopano! Pezani ma SARM abwino kwambiri kuchokera pamtengo wapamwamba Ma ARV UK sitolo - The Masitolo a SARM.

Mlingo Wovomerezeka Wa Yohimbine

Mlingo woyenera wa Yohimbine wa amuna ndi 25-50mg tsiku lililonse, wogawika magawo awiri ofanana. Izi zimayenera kumwa ndikudya ndipo makamaka mphindi 30-45 musanachite masewera olimbitsa thupi, patadutsa milungu eyiti mpaka khumi ndi iwiri. Kwa amayi, mlingo woyenera wa Yohimbine ndi 10-20mg tsiku lililonse, wogawika magawo awiri ofanana. Azimayi amayenera kumwa mankhwalawa ndikudya ndipo makamaka mphindi 30-45 isanakwane gawo lochita masewera olimbitsa thupi, patadutsa milungu eyiti mpaka khumi ndi iwiri.

Yohimbine imathandizanso pochiza anorgasmia (yomwe imadziwikanso kuti kutayika kwamankhwala osokoneza bongo). Kafukufuku adawonetsa kuti miyezo ya tsiku ndi tsiku ya 20mg, yokhala ndi 5 mg yokwera mpaka 50mg tsiku lililonse ndiyabwino pakuwongolera anorgasmia.

Yohimbine Cycle Kwa Amuna

mlungu	Yohimbine	GW-501516	Thandizo la PCT	Thandizo Loyenda
1	25mg tsiku lililonse	20mg tsiku lililonse
2	25mg tsiku lililonse	20mg tsiku lililonse
3	25mg tsiku lililonse	20mg tsiku lililonse
4	25mg tsiku lililonse	20mg tsiku lililonse
5	25mg tsiku lililonse	20mg tsiku lililonse
6	50mg tsiku lililonse	20mg tsiku lililonse
7	50mg tsiku lililonse	20mg tsiku lililonse
8	50mg tsiku lililonse	20mg tsiku lililonse		Makapisozi 3 patsiku
9	50mg tsiku lililonse	20mg tsiku lililonse		Makapisozi 3 patsiku
10	50mg tsiku lililonse	20mg tsiku lililonse		Makapisozi 3 patsiku
11	50mg tsiku lililonse	20mg tsiku lililonse		Makapisozi 3 patsiku
12	50mg tsiku lililonse	20mg tsiku lililonse		Makapisozi 3 patsiku
13			Makapisozi 3 patsiku
14			Makapisozi 3 patsiku
15			Makapisozi 3 patsiku
16			Makapisozi 3 patsiku

 

Malangizo ndi Zosamalitsa

Yohimbine siyikulimbikitsidwa kwa ana ndi amayi omwe ali ndi pakati kapena akuyamwitsa. Iyenera kugwiritsidwa ntchito mosamala kwambiri mukamamwa limodzi ndi mankhwala a kuthamanga kwa magazi, phenothiazines, kapena tricyclic antidepressants. Mgwirizanowu sulimbikitsidwa kwa anthu omwe ali ndi matenda amisala komanso mavuto a impso.

Kuphatikiza apo, chisamaliro chachikulu komanso kulimbikira kuyenera kuwonedwa pamene mankhwalawa amaperekedwa kwa anthu omwe ali ndi mbiri yazachipatala ya kutuluka kwachisoni kapena omwe akuchitiridwa chithandizo chofananira cha tricyclic antidepressants kapena mankhwala ofanana omwe angasokoneze kagayidwe ka norepinephrine kapena Kutenga kwa neuronal.

Yohimbine sayenera kuzunzidwa chifukwa ndi chida champhamvu. Kuzunzidwa kwa Yohimbine kumatha kubweretsa zovuta monga kunyoza, kuda nkhawa, chizungulire, komanso kupweteka mutu. Kugwiritsa ntchito Yohimbine sikuyenera kupangidwa limodzi ndi ma hemophiliacs komanso sikuyenera kugwiritsidwa ntchito ndi iwo omwe achita opaleshoni posachedwa chifukwa amachepetsa kuundana. Ochepetsa magazi ngati warfarin, aspirin, ndi heparin sayenera kutengedwa limodzi ndi Yohimbine.